Journal of Drug Design and Development

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Table of Content: Volume 3, Issue 1

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Research Article Pages 54-59

Quantitative Structure-Activity Relationship (QSAR) Study of A Series of 2-Thioarylalkyl Benzimidazole Derivatives by the Density Functional Theory (DFT)

Authors: DigréEkozias Béké, Mawa Koné and Fatogoma Diarrasouba

Abstract: In this work, we used the quantum density theory (DFT), B3LYP / 6-311G (d, p) to establish a QSAR (Quantitative Structure Activity Relationships) model on a series of molecules derived from 2-thioarylalkyl-1H -Benzimidazole. This model is built with molecular descriptors and anthelmintic activities against the Haemonchus contortus. This model has as statistical

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Review Article Pages 49-53

Importance of Alpha Lipoic Acid (ALA): Antidiabetic and Antioxidant Effects

Authors: Anna Votano, Alessia Bonofiglio, Federica Catalano and Claudia Paone

Abstract: Within our organism, during the numerous metabolic reactions, free radicals (or ROS) are formed, unstable molecules that contain one or more unseated electrons and are responsible for oxidative stress. The organism must cope with and eliminate these free radicals that can create indiscriminate damage on biological macromolecules. To counteract their action and prevent cellular oxidation, the presence of molecules defined as antioxidants is fundamental. Some studies

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